What are the side effects of Nintedanib?

Nintedanib(Nintedanib) is a tyrosine kinase inhibitor indicated for the treatment and management of idiopathic pulmonary fibrosis, systemic sclerosis-related interstitial lung disease, and interstitial lung diseases with progressive phenotypes. What are the side effects of Nintedanib(Nintedanib)?

Nintedanib(Nintedanib)Common side effects includeDiarrhea (62%), Nausea (24%), Abdominal pain (15%), Elevated liver enzymes( 14%), vomiting (12%), decreased appetite (11%), weight loss (10%), bleeding events (10%), headache (8%), hypertension (5%), arterial thromboembolic events (2.5% ), myocardial infarction (1.5%), bronchitis (1.5%), hypothyroidism (1.1%), pneumonia (0.7%), lung malignant tumors (0.3%), gastrointestinal perforation (0.3%), etc.

Nintedanibis a substrate for the transporterp-glycoprotein that moves absorbed material back into the intestinal lumen. P-The glycoprotein inhibitor ketoconazole is known to increase nintedanibplasma levels 1.8fold; other inhibitors such as erythromycin or cyclosporine are expected to have similar effects. On the other hand, the P-glycoprotein inducer rifampicin halvenintedanibplasma levels; other inducers such as carbamitrazine, phenytoin or St. John's wort may also decrease plasma levels. This medication uses ethanesulfonic acid in its salt form. This salt, nintedanib esilate, is a yellow crystalline solid with a melting point of 244°C (471°F) to 251°C (484°F). It has poor solubility in water, but slightly better solubility in water. The concentration of dimethyl sulfoxide is 25micrograms/liters. If you want to get more high-quality information, you can contact YaoDe. YaoDe will do its best to learn more about high-quality overseas drugs for you.

xa0