Is crizotinib a targeted drug?

Crizotinib is a first-generation targeted drug used to treat non-small cell lung cancer (NSCLC), anaplastic large cell lymphoma (ALCL), and anaplastic lymphoma kinase (ALK)-positive inflammatory myofibroblastic tumor (IMT). Crizotinib targets ALK and MET mutations and has positive implications for patients.

The most common adverse reactions in adult patients with non-small cell lung cancer (≥25%) are visual disturbance, nausea, diarrhea, vomiting, edema, constipation, elevated transaminases, fatigue, decreased appetite, upper respiratory tract infection, dizziness and neuropathy. The most common adverse reactions in patients with ALCL(≥35%)are diarrhea, vomiting, nausea, visual impairment, headache, musculoskeletal pain, stomatitis, fatigue, decreased appetite, fever, abdominal pain, cough and pruritus. Grade 3-4 laboratory abnormalities(≥15%)are neutropenia, lymphopenia and thrombocytopenia. IMTThe most common adverse reactions(≥35%)in adult patients are visual disturbance, nausea and edema. IMTThe most common adverse reactions in children (≥35%)are vomiting, nausea, diarrhea, abdominal pain, rash, visual impairment, upper respiratory tract infection, cough, fever, musculoskeletal pain, fatigue, edema, constipation and headache.

For patients with metastatic (cancer that has spread) NSCLC, the recommended dose of crizotinib is 250 mg taken orally twice daily.

For patients with systemicALCLthe recommended dose of crizotinib is280 mg/m2based on body surface area, taken orally twice daily.

For patients with unresectableIMT, the recommended adult dose of crizotinib is 250 mg taken orally twice daily, and the recommended pediatric dose is 280 mg/m2Based on body surface area, take orally twice daily. See full prescribing information for indications for dosage adjustments in patients with moderate or severe hepatic impairment or severe renal impairment. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.

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