Dasatinib resistance management

In chronic myelogenous leukemia, the transition from drug-sensitive to drug-resistant disease is poorly understood. Exploratory sequencing of gene transcripts is used clinically to determine the resistance mechanisms of dasatinib (Dasatinib)-resistant cell line models. Among them, BCR-ABL1 overexpression, BCR-ABL1 kinase domain mutations, and overexpression of the small molecule transporter ABCG2 were identified as dasatinib resistance mechanisms. The acquisition of mutations follows a sequence corresponding to an increase in the fitness of selection associated with each resistance mechanism. In addition, it was also demonstrated that ABCG2 overexpression conferred partial resistance to ponatinib (AP24534).

So there are other options after dasatinib treatment fails. Changing to anothertki may be an option. In recent years, research on the third-generation TKI inhibitor ponatinib has shown promise. Ponatinib blocks native and mutated BCR-ABL. Allogeneic hematopoietic stem cell transplantation can also be used in patients who have blast crisis at diagnosis, T315I and other BCR-ABL1 mutations, and are resistant or intolerant to all TKIs. Everyone’s constitution is different and their resistance to drugs is also different. If drug resistance develops after using drugs, please inform your doctor in time. The doctor will investigate through genetic testing and other methods. Patients are not allowed to adjust the drug dosage by themselves.

The original drug of dasatinib has been launched in China and is included in the medical insurance. Currently, reimbursement is only available to eligible patients. Common specifications The price of each box of 50mg*60 tablets may be around RMB 10,000. The original drug overseas is even more expensive. Dasatinib generics are also sold overseas. The ingredients of the drug are basically the same as those sold domestically and abroad, but the price is cheap. For example, the price of a box of 50mg*60 tablets produced by an Indian pharmaceutical factory may be several hundred yuan (the price may fluctuate due to exchange rates).