Do I need to take Dasatinib for life?

Dasatinib (Dasatinib) is used as a long-term treatment and has been used in clinical trials for 5 years. Doctors may usually recommend that patients continue taking it as long as tests show it is working well, or the condition is not getting worse, or there are no serious side effects while taking it. If these conditions change, the doctor will discuss the patient's options and whether treatment needs to be discontinued.

In theDASISION clinical trial, in which patients took dasatinib or imatinib for 5 years, the estimated 5-year overall survival rates for dasatinib and imatinib were 91% and 90%, respectively. When using dasatinib as first-line treatment for chronic phase chronic myelogenous leukemia, 54% of patients demonstrated a complete cytogenetic response by 3 months. In contrast, 31% of patients taking imatinib had a complete cytogenetic response at the same time. A complete cytogenetic response occurs when there are no Ph-positive metaphases in the bone marrow sample. The complete cytogenetic response rate with dasatinib was 54% in the first 3 months; 73% in the first 6 months, and 78% in the first 9 months.

The original drug of dasatinib has been launched in China and is included in the medical insurance. Currently, reimbursement is only available to eligible patients. Common specifications The price of each box of 50mg*60 tablets may be around RMB 10,000. The original drug overseas is even more expensive. Dasatinib generics are also sold overseas. The ingredients of the drug are basically the same as those sold domestically and abroad, but the price is cheap. For example, the price of a box of 50mg*60 tablets produced by an Indian pharmaceutical factory may be several hundred yuan (the price may fluctuate due to exchange rates).