Dasatinib side effects and contraindications

Dasatinib (Dasatinib) is a powerful anti-leukemia drug, but it may also cause some side effects. Dasatinib was well tolerated by patients reported in clinical trials; however, side effects also occurred in a small proportion of patients, and these toxicities were managed by dose reduction, interruption, or discontinuation. The use of dasatinib may be contraindicated in patients who are allergic to dasatinib or to any of its components.

According to the results of clinical studies, the most common non-hematological adverse events are gastrointestinal disorders, such as abdominal pain, diarrhea, nausea, vomiting, gastrointestinal bleeding, mucosal inflammation, abdominal distension and dyspepsia. Respiratory problems such as pleural effusion, dyspnea, cough, and even pulmonary hypertension are less common. Nervous system disorders, including headaches and neuropathy, are also less common. The incidence of adverse cardiac events such as left ventricular dysfunction, heart failure, cardiomyopathy, ventricular failure, diastolic dysfunction, andQT interval prolongation was low. Other toxicities such as cutaneous sequelae, serious infections, menstrual irregularities, dizziness, appetite disturbance, and bleeding have been reported.

The original drug of dasatinib has been launched in China and is included in the medical insurance. Currently, reimbursement is only available to eligible patients. Common specifications The price of each box of 50mg*60 tablets may be around RMB 10,000. The original drug overseas is even more expensive. Dasatinib generics are also sold overseas. The ingredients of the drug are basically the same as those sold domestically and abroad, but the price is cheap. For example, the price of a box of 50mg*60 tablets produced by an Indian pharmaceutical factory may be several hundred yuan (the price may fluctuate due to exchange rates).