When is the best time to take Palbociclib?

Patients should take palbociclib as directed by their doctor, which is usually an oral medication taken with a meal. It is recommended that the drug be taken at the same time each day to ensure that the drug maintains stable concentrations in the body. Patients should avoid eating or drinking foods or drinks containing grapefruit or its juice before, during, and after taking palbociclib. Grapefruit may affect the metabolism and effects of this drug.

Mean maximum observed concentrations are generally observed between 6 and 12 hours after oral administration. The mean absolute bioavailability of palbociclib after an oral dose of 125 mg is 46%. After repeated dosing once daily, a steady state is reached within 8 days. Approximately 13% of the population absorbed and was exposed to very low amounts of palbociclib under fasting conditions. Food intake increased palbociclib exposure in this small population but did not alter palbociclib exposure in the remaining population to a clinically relevant degree. Therefore, food intake reduced the between-subject differences in palbociclib exposure, which supports administration of palbociclib with food.

PalbociclibThe original drug has been launched in China and has been included in medical insurance. Currently, reimbursement is only available to patients who meet the indications. The common specifications100mg*21 pills may cost more than 6,000 yuan per box, while the original drug sold overseas is more expensive. The price of 125mg*21 pills per box may be around 10,000 yuan (the price may fluctuate due to exchange rates). Dasatinib generics are also sold overseas. The ingredients of the drug are basically the same as those sold domestically and abroad, but the price is cheap. For example, the price of a box of 125mg*21 tablets produced by a Bangladesh pharmaceutical factory may be several hundred yuan (the price may fluctuate due to exchange rates).