Mitotane (MITOTANE) usage and dosage

MITOTANE is currently the only drug approved for adrenocortical cancer. Mitotane is indicated for the treatment of patients with inoperable functional or non-functioning adrenocortical carcinoma.

The recommended initial dose of mitotane is 2 grams to 6 grams taken orally in three or four divided doses per day. Gradually increase the dose until the blood concentration reaches 14-20mg/L, or reaches the tolerance level. In patients with adrenal crisis in shock or severe trauma, discontinue mitotane until recovery. In patients with CNS toxicity, discontinue mitotane until symptoms resolve and restart at a lower dose 7 to 10 days after resolution of symptoms. Mitotane is available as 500white, round, biconvex, scored tablets, split in two, with "BL" printed on the other side instead of "L1".

Mitotane is a strongCYP3A inducer. Concurrent use ofmitotanemay decreasethe concentrations of CYP3Asubstrates, thereby reducing the efficacy of these substrates. Avoid coadministration ofmitotanewith certainCYP3A4substrates as minimal concentration changes may result in treatment failure. If concomitant use cannot be avoided, increase the CYP3A substrate dose according to the approved product labeling. When coumarin anticoagulants are administered to patients receivingmitotane, coagulation tests should be monitored and the anticoagulant dose adjusted as needed. There are regular generic drugs on the market in Laos, and the retail price is about 500mg100 tablets3 about one thousand. If you want to get more high-quality information, you can contact Yaode. Yade will do its best to learn more about high-quality overseas drugs for you.

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