What is the personal cost of Crizotinib after medical insurance?

In October 2018October, Crizotinib was approved for marketing by the State Food and Drug Administration of China. Domestic imported Crizotinib retails The price 200mg 60 tablets 8 is more than a thousand. Each province’s medical insurance policy and reimbursement ratio are different, and the individual fees are different.

The main side effects for patients with ALK-positive metastatic NSCLC (≥25%) include visual impairment, nausea, diarrhea, vomiting, edema, constipation, elevated transaminase concentrations, fatigue, decreased appetite, upper respiratory tract infection, dizziness, and neuropathy. Main side effects for patients with LCL (≥35%) includediarrhea, vomiting, nausea, visual impairment, headache, musculoskeletal pain, stomatitis, fatigue, decreased appetite, fever, abdominal pain, cough, and itching. Crizotinib is mainly metabolized by CYP3A, in vitro, inhibits CYP2B6, but does not inhibit CYPisoenzyme1A2, span>2C8, 2C9, 2C19 or 2D6, or UGT 1A1, 1A4, 1A6, 1A9 or 2B7, does not induceCYPisoenzymes1A2, 2B6, 2C8, 2C9, 2C19 or 3A. In vitro, P-Inhibitor and substrate of glycoproteins, inhibits organic cation transporter(OCT) 1 and OCT 2; does not inhibit organic anion transporter(OATP) B1, OATP1B3, renal organic anion transporter(OAT) 1, OAT3 or bile salt export pump(BSEP). Crizotinib may increase systemic exposure and toxicity. Avoid concomitant use of strong CYP3A inhibitors, if concomitant use cannot be avoided, reduce the crizotinib dose to 250 mg once daily. When discontinuing a strongCYP3Ainhibitor, return the crizotinib dose to the dose before initiating theCYP3Ainhibitor, use moderateCYP3Ainhibitors with caution. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.