What type of drug is Palbociclib?

Palbociclib (Palbociclib) is a targeted drug, a CDK4/6 inhibitor, used to treat patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. CDK4/6 represents cell cycle regulatory protein-dependent kinases 4 and 6. These kinases play an important role in the process of cell suppression of metastasis.

Palbociclib inhibitsCDK4/6 activity, preventing cancer cells from entering the next stage of the cell cycle, thereby slowing down the growth and spread of cancer cells. Palbociclib is commonly used to treat breast cancer. It is used as first-line treatment, in combination with other drugs such as estrogen receptor agonists , to treat estrogen receptor-positive (ER+) breast cancer. The use of palbociclib can prolong progression-free survival and improve treatment efficacy. However, it should be noted that palbociclib is not suitable for all breast cancer patients, and doctors will evaluate whether it is appropriate to use this drug based on specific circumstances.

PalbociclibThe original drug has been launched in China and has been included in medical insurance. Currently, reimbursement is only available to patients who meet the indications. The common specifications100mg*21 pills may cost more than 6,000 yuan per box, while the original drug sold overseas is more expensive. The price of 125mg*21 pills per box may be around 10,000 yuan (the price may fluctuate due to exchange rates). Palbociclib generics are also sold overseas. The ingredients of the drug are basically the same as those sold domestically and abroad, but the price is cheap. For example, the price of a box of 125mg*21 tablets produced by a Bangladesh pharmaceutical factory may be several hundred yuan (the price may fluctuate due to the exchange rate).