Can Palbociclib treat lung cancer?

Palbociclib (Palbociclib) is a drug commonly used in the treatment of breast cancer. Its mechanism of action is by inhibiting the proliferation of tumor cells. However, palbociclib is not currently considered a standard treatment for lung cancer. Lung cancer is a complex and diverse disease, and treatment options may vary depending on the subtype and stage. In general, the treatment of lung cancer usually includes surgery, radiation therapy, chemotherapy, targeted therapy and immunotherapy.

Palbociclib is the first oral CDK inhibitor approved by the U.S. Food and Drug Administration (FDA) for the treatment of metastatic hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer in combination with anti-hormone therapy. CDKN2A deletions or mutations commonly occur in non-small cell lung cancer (NSCLC), and one study observed 1 patient with a partial response and 6 patients with SD with stable disease. Among patients, the disease control rate was 31% (90% CI, 19%-40%), the median PFS was 8.1 weeks (95% CI, 7.1-16.0 weeks), and the median OS was 21.6 weeks (95% CI, 14.1-41.1 weeks). Palbociclibmonotherapy demonstrated evidence of modest antitumor activity in heavily pretreated CDKN2A-altered NSCLC patients.

PalbociclibThe original drug has been launched in China and has been included in medical insurance. Currently, reimbursement is only available to patients who meet the indications. The common specifications100mg*21 pills may cost more than 6,000 yuan per box, while the original drug sold overseas is more expensive. The price of 125mg*21 pills per box may be around 10,000 yuan (the price may fluctuate due to exchange rates). Generic drugs of palbociclib are also sold overseas. The ingredients are basically the same as those sold domestically and abroad, but the price is cheap. For example, the price of 125mg*21 tablets produced by a Bangladesh pharmaceutical factory may be several hundred yuan per box (the price may fluctuate due to exchange rates).