Are there generic versions of Palbociclib?

The original drug of Palbociclib (Palbociclib) has been launched in many countries. It is understood that there are also many countries overseas producing generic drugs of Palbociclib. Its pharmaceutical ingredients are basically the same as those of the original drug, and it is suitable for the treatment of hormone receptor positive (HR). +) , The treatment of HER2-negative (HER2-) advanced breast cancer (ABC), when used in combination with endocrine therapy, may have slight differences in production specifications and prices. Common generic drug manufacturers include Laos ASEAN Pharmaceuticals, Bangladesh Yaopin International, etc.

Pabociclib is the first CDK 4/6 inhibitor to be shown to be effective when combined with endocrine therapy in patients with treatment-naïve or previously treated HR-positive, HER2-negative metastatic breast cancer. The introduction of CDK inhibitors has changed the treatment model for HR-positive, HER2-negative metastatic breast cancer, allowing patients treated in clinical trials to have a progression-free survival of approximately 24 months, with appropriate tolerability and easily controllable side effects, and no patient suspended treatment due to toxic reactions.

PalbociclibThe original drug has been launched in China and has been included in medical insurance. Currently, reimbursement is only available to patients who meet the indications. The common specifications100mg*21 pills may cost more than 6,000 yuan per box, while the original drug sold overseas is more expensive. The price of 125mg*21 pills per box may be around 10,000 yuan (the price may fluctuate due to exchange rates). Palbociclib generics are also sold overseas. The price of a box of 125mg*21 tablets produced by a Bangladeshi pharmaceutical factory may be several hundred yuan (the price may fluctuate due to the exchange rate), which is cheap.