Can Avatrombopag be taken long-term?

AvatrombopagisbyDova PharmaceuticalsDeveloped in20185Menstrual AmericaFDAAvatrombopag is approved for the treatment of thrombocytopenia in adult patients with chronic liver disease (CLD) scheduled to undergo surgery and for the treatment of adult patients with chronic immune thrombocytopenia.

Avatrombopag(Avatrombopag)Long-term use is generally not recommended. Long-term use may cause adverse reactions, such as fever, abdominal pain, nausea, headache, fatigue and peripheral edema, fatigue, contusions, nosebleeds, upper respiratory tract infections, joint pain, gum bleeding, etc. Patients need to follow the doctor's advice when taking avatrombopag, do not change the dose on their own, check the platelet count on time, and inform the doctor in time if a serious reaction occurs. Avatrombopag is taken orally once a day for 5 consecutive days with food. 5Recheck after 5 days and inform the doctor of platelet count in time.

Single dose10 mg (0.5 times the lowest approved dose) to 80 Avatrombopag exhibits dose-proportional pharmacokinetics at mg (1.3 times) of the highest recommended dose. The geometric mean maximum concentration of avatrombopag (%CV) in healthy subjects after taking 40 mg of avatrombopag was 166 (84%) ng/mL, time-The area under the concentration curve is extrapolated to infinity(AUC0-inf)< /span>4198Example(83%) ng.hr/mL.The pharmacokinetics of avatrombopag were similar in healthy subjects and people with chronic liver disease.

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