Can Avatrombopag completely cure platelets?

AvatrombopagIt is used to increase the level of platelets in the blood and is suitable for patients with low platelet levels(Thrombocytopenia span>)In patients with chronic liver disease(CLD)and who plan to undergo surgery or chronic immune thrombocytopenia(ITP ) and does not respond well to other treatments.

Avatrombopag does not cure thrombocytopenia and does not normalize platelet counts. The production of platelets in the body begins with hematopoietic stem cells, which develop into megakaryocytes, which produce platelets. Avatrombopag (a thrombopoietin receptor agonist) tells the body to make more HSCs develop into megakaryocytes. Once there are more megakaryocytes, the number of platelets that can be made increases, causing platelet levels to rise.

It takes approximately 10 to 13 days for platelet levels to rise. For patients with chronic liver disease who are scheduled to undergo surgery, avatrombopag should be started 10 to 13 days before planned surgery. For patients with chronic immunity, the starting dose is 20 mg once daily, then adjust the dose or frequency of administration to maintain a platelet count greater than or equal to 50 x109/L, the maximum dose is 40mg,After starting treatment with avatrombopag, check the platelet count every week until the stable platelet count is greater than or equal to 50 x109/L, then check the platelet count monthly. When you stop taking avatrombopag, check your platelet count every week for at least 4 weeks.

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