Which one is more effective, eltrombopag or avatrombopag?

Eltrombopag is a thrombopoietin receptor agonist indicated for the treatment of immune thrombocytopenia in patients with inadequate response to glucocorticoids, immunoglobulins, or splenectomy. It is also approved for the first-line treatment of severe aplastic anemia in children aged 2 years and older and adults. It is also used to prevent thrombocytopenia in adults with chronic hepatitis C treated with interferon. Eltrombopag not only promotes the proliferation and differentiation of megakaryocytes and the production of platelets, but also promotes the proliferation and differentiation of bone marrow hematopoietic stem cells, thereby improving hematopoietic function.

Avatrombopag is indicated for the treatment of thrombocytopenia in adult patients with chronic liver disease scheduled for surgery and for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia who have had an inadequate response to prior therapy.

One trial showed: Exposure time—The average exposure time of avatrombopag was 2.8 times that of eltrombopag and 3.8 times that of placebo. Cumulative response time—Avatrombopag has a longer cumulative response time. Response rate—Avatrombopag has a higher early response rate. Compared with baseline, platelet count increases at each visit were higher with avatrombopag. Patients with ITP who received avatrombopag had a lower incidence of bleeding. The above results show that avatrex has a better effect.

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