What are the side effects of Delamanid?

Delamanid(Delamanid) is an anti-tuberculosis drug derived from nitrodihydroimidazole compounds synthesized from mycolic acid that inhibits the bacterial cell wall1. It is used in combination regimens to treat multidrug-resistant and extensively drug-resistant tuberculosis (TB). The emergence of multidrug-resistant and extensively drug-resistant tuberculosis poses clinical challenges for patients, as the disease is associated with higher mortality and inadequate treatment response to standardized antituberculous therapy with isoniazid and rifampicin. MDR-TB may also require more than 2 years of chemotherapy and second-line treatment, with a narrow therapeutic index. What are the side effects of Delamanid(Delamanid)?

Delamanid(Delamanid)Common side effects includegastrointestinal disorders, nausea, vomiting, diarrhea, abdominal pain, indigestion, and oropharyngeal pain. Systemic diseases and administration site conditions: Discomfort, fatigue, including hypokalemia, loss of appetite, etc.

Delamanidhas previously been shown to have relatively few drug-drug interactions related to its non-cytochromeP450mediated metabolism. New in vitro data indicate no significant interactions with drug transporters that affect drug absorption, distribution, and excretion. Delamanid is combined with the first-line antituberculosis drugs rifampicin, isoniazid(INH), PZA and ethambutol(EMB) as well as antiretroviral drugs The drugs ritonavir, tenofovir, efavirenz (EFV) and LPV/r do not have significant interactions, thus limiting the potential for reduced safety or effectiveness when used concomitantly. There is an original research version in Russia, and each box is about 1 more than a thousand. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.