How much does Delamanid cost?

Delamanid(Delamanid) is a nitrodihydroimidazole derivative and a new anti-tuberculosis drug that inhibits the synthesis of mycolic acid and shows effective activity against drug-resistant strains of Mycobacterium tuberculosis in vitro and in vivo. In a clinical study involving patients with multidrug-resistant or extensively drug-resistant tuberculosis, treatment with delamanid in combination with an optimized background regimen recommended by WHO was associated with improved treatment outcomes and reduced mortality. Spontaneous resistance todelamaniwas observed during treatment, in which mutations in one of the5species ofF420coenzymes responsible fordelamanibioactivation contribute to this effect. Delamanidis approved by EMA and marketed under the brand name Deltyba for oral tablets. It is marketed by Otsuka Pharmaceutical Co., Ltd. (Tokyo, Japan).

Delamanid(Delamanid)How much does it cost?

Dramani has been launched in the country and is included in the national Class B medical insurance. The retail price in domestic pharmacies is around 6450 yuan per box of 50 mg and 60 tablets. At present, there is also an original research version in Russia. The hospital retail price is more than 1,000 per box of 50 mg and 48 tablets. The specific price is subject to the hospital retail price.

After a single oral dose of 100 mg delamanid , the peak plasma concentration was 135 ng/mL . 10-14The steady-state concentration is reached after 5. Plasma exposure to delamanid increases disproportionately with increasing doses. In animal models (dog, rat, mouse)the oral bioavailability of delamanid has been reported to be 35%–60%. Absolute oral bioavailability in humans is estimated to range from 25% to 47%. When administered with a standard meal, human oral bioavailability is increased approximately 2.7-fold compared to fasted conditions because delamanid exhibits poor water solubility.If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.