What are the side effects of Selumetinib?

Selumetinibis an oral small molecule mitogen-activated protein kinase1 and 2 (MEK1/2)inhibitors for the treatment of symptomatic, refractory fibromas in neurofibromatosis type 1Neurofibromatosis(NF1). Selumetinibis associated with transient and often mild elevations in serum aminotransferase levels during treatment but not with clinically apparent cases of acute liver injury.

Selumetinib(Selumetinib)The most common adverse reactions occurred in 40% or more of patients and included vomiting, rash, abdominal pain, diarrhea, nausea, dry skin, fatigue, musculoskeletal pain, pyrexia, acneiform rash, stomatitis, headache, paronychia, and pruritus.

1.Cardiovascular disease is common (10% or above):Reduced ejection fraction(Up to23%), sinus tachycardia(20%), elevated blood pressure and hypertension(less than20%).

2.The most common dermatological rashes include dermatitis acneiform(54%), maculopapular rash(39%), and eczema(28%).

3.Gastrointestinal system Very common (more than 10%):Vomiting(82%), abdominal pain(76%), diarrhea(up to span>77%), nausea(up to73%), stomatitis Including oral ulcers(50%), constipation(34%), and elevated lipase (32%), dry mouth(less than 20%), and elevated amylase(18%). Unreported frequency (Events from other studies):Perforation, colitis, ileus, ileus.

3.HematologySystem Very common(10%or more):Albumin reduction(51%), decreased hemoglobin(41%), neutropenia(33%), lymphopenia(20%).

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5.Metabolism is common(10%above):Increased potassium(27%), decreased appetite(22%), weight gain(less than20%), decreased potassium(18%), increased alkaline phosphatase(18%), increased sodium(18%), decreased sodium(16%).

6.Musculoskeletal is common (10% or more):Increase creatine phosphokinase(Up to79%), musculoskeletal pain, including pain in the extremities, back and neck(58%). Unreported frequency (Events from other studies):Rhabdomyolysis.

7.Nervous system is common (10%or more):Headache(48%).

8.Vision is common(10%or more):Visual impairment, including blurred vision, photophobia, cataracts, and high intraocular pressure(less than20%)

Rare events reported in other studies (0.1% to1%):Retinal vein occlusion(RVO), retinal pigment epithelial detachment(RPED), central serous retinopathy.

9.Respiratory system Very common (10%or above):Nistaxis(28%), dyspnea, including dyspnea on exertion and at rest(less than20%).

10.Kidney is common(10%or more):hematuria(22%), proteinuria(22%), acute kidney injury(less than20%). There is an original version of selumetinib available overseas, with a retail price of 10 mg 60 tablets 50,000 around . If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.

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