What does Sotorasib do?

Sotorasib is an inhibitor targeting KRAS G12C mutations. It is mainly used to treat KRAS G12C mutated non-small cell lung cancer (NSCLC). KRAS G12C is a mutation in the RAS family gene, which is particularly common in NSCLC and other cancers. The mechanism of action of sotoracib makes it an innovative, targeted therapy.

1.InhibitionKRAS G12Cmutant: Sotoracib blocks abnormal signaling pathways in cancer cells by specifically interfering with the activity of KRAS G12Cmutant. KRAS G12CThe mutation drives the growth, division, and spread of cancer cells, and the inhibitory effect of sotoracib helps slow or even stop these abnormal processes, thereby hindering tumor development.

2.Blocking tumor growth: By acting on the KRAS G12C mutation, sotoraxib is expected to block the growth of cancer cells and limit their ability to spread to surrounding tissues and organs. This targeted effect is expected to slow disease progression and improve patient response to treatment.

3.Precision targeted therapy: Due to its high selectivity for KRAS G12Cmutation, sotoraxib is considered a precision targeted therapy. Compared with traditional chemotherapy drugs, precision treatment is more likely to minimize damage to normal cells and improve the safety of treatment.

4.Provide new options for refractoryNSCLCpatients: KRAS G12Cmutated non-small cell lung cancer is usually refractory to traditional treatments. The emergence of sotoracib provides new treatment hope for this patient group and is expected to improve treatment effects and patient survival rates.

The original drug of sotoraxibu has not yet been launched in China, so patients cannot purchase it domestically and need to purchase sotolasibu through overseas channels. The price of the original version of sotorasibu in Hong Kong, China, with the specifications of 120mg*240 tablets, is around 8 million, and the price of the European version of the original drug with the same specifications is around 4 million, which is relatively expensive. The cheaper ones are the generic drugs marketed abroad. For example, the price of generic drugs in Laos and Bangladesh is around two to three thousand yuan. The price is relatively cheap, and the ingredients of foreign generic drugs are basically the same as the original drugs.