What is the real purchase price of generic drugs of Sotolaxib?

Sotorasib is an innovative anti-cancer drug that is an inhibitor of KRAS G12C mutations and is used to treat KRAS G12C mutant non-small cell lung cancer (NSCLC). KRAS G12CMutation is a common genetic variation in a variety of cancers, and Sotoracib is designed to specifically intervene in this specific gene mutation, providing a new and precise treatment option.

The original drug of sotorasibu has not yet been launched in China, so patients cannot purchase it domestically and need to purchase sotorasibu through overseas channels. The price of the original version of sotorasibu in Hong Kong, China, with the specifications of 120mg*240 tablets, is around 8 million, and the price of the European version of the original drug with the same specifications is around 4 million, which is relatively expensive. The cheaper ones are the generic drugs marketed abroad. For example, the price of generic drugs in Laos and Bangladesh is around two to three thousand yuan. The price is relatively cheap, and the ingredients of foreign generic drugs are basically the same as the original drugs.

The mechanism of action of sotorasiib is mainly againstKRAS G12Cmutant. KRASThe protein is responsible for regulating cell growth and differentiation, and the G12C mutation makes this process extremely active and promotes the uncontrolled proliferation of cancer cells. Sotorasiib specifically binds to the KRAS G12C protein and blocks its normal signaling pathway, effectively inhibiting the development of tumors.

Clinical trial data show that sotoraxib shows certain efficacy in patients with KRAS G12Cmutant non-small cell lung cancer. After receiving drug treatment, some patients' tumor growth was significantly inhibited, and some even experienced tumor shrinkage. This provides a new, promising treatment option for patients who have previously had limited response to conventional treatments.