How effective is Acalabrutinib?

Acalabrutinib is a drug used to treat various types of non-Hodgkin lymphoma, including mantle cell lymphoma (MCL )and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma(CLL/SLL). Acalabrutinibcan be used for both recurrence and first treatment.

Acalabrutini(Acalabrutinib)How effective is it?

Acalabrutini(Acalabrutinib) is aBrutontyrosine kinase inhibitor approved for use in patients with chronic lymphocytic leukemia(CLL). ASCENDisacalabrutinibwith investigators in relapsed/refractory(R/R) A pivotal phase 3 study of idelalisib plus rituximab (IdR) or bendamustine plus rituximab (BR) in patients with CLL. In the mainASCENDanalysis(median follow-up16.1months), acalabrutinibshowed better efficacy than IdR/BR and acceptable tolerability. Here, we report final ~4 year follow-up results. R/R CLLPatients received oral acalabrutinib 100 mg twice daily until progression or unacceptable toxicity, or the investigator's choice IdR or BR. A total of 310patients were enrolled. At a median of 46.5 months(acalabrutinib) and 45.3During months(IdR/BR) follow-up, acalabrutinibsignificantly prolonged investigator-assessed progression-free survival(PFS)andIdR/BR. Acalabrutinib is a white to yellow powder with solubility dependent on pH. It is easily soluble in water when the pH value is lower than 3 and is almost insoluble when the pH value is higher than 6. CALQUENCE capsules for oral administration contain 100 mg acalabrutinib and the following inactive ingredients: silicified microcrystalline cellulose, partially pregelatinized starch, magnesium stearate, and sodium starch glycolate. The capsule shell contains gelatin, titanium dioxide, yellow iron oxide, FD&Cblue2, and is printed with edible black ink. The price of generic acalabrutinib is about 6,000 to 7,000. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.