How much can you buy genuine trametinib?

Trametinib (Trametinib) is a reversible, highly selective allosteric inhibitor of MEK1 and MEK2 with anti-cancer activity against metastatic melanoma harboring BRAF V600 mutations. The activity of trametinib has been evaluated in the treatment of multiple cancers and is currently approved as monotherapy in subjects with BRAF V600E/K-mutated unresectable or metastatic melanoma, non-small cell lung cancer, or in combination with dabrafenib for the same indication.

Trametinib is aMEK inhibitor. MEK 1 and 2 are proteins involved in cell proliferation, an uncontrolled process during tumor formation. Inhibiting this process helps slow this proliferation and leads to cell death, which helps slow tumor growth. Dabrafenib is a cancer growth retardant. It works by targeting certain proteins made by the BRAF gene that allow cells to grow uncontrollably. By blocking these proteins, dabrafenib can stop or slow the growth of tumor cells. Clinical trials have shown that the combination of these two drugs can enhance the clinical efficacy of children with BRAF mutations.

The original drug of Trametinib has been launched in China and is included in the scope of medical insurance, but it may only be available to patients who meet the indications. The price of 2 mg*30 tablets is more than RMB 10,000. The original drug of Trametinib sold overseas, with the price of 2 mg*30 tablets, is more than RMB 7,000 (the price may fluctuate due to exchange rates). There are also generic trametinib drugs produced in other countries overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of a 2 mg*30 tablet of a generic drug produced by a Lao pharmaceutical factory is more than 2,000 yuan (the price may fluctuate due to the exchange rate).