Trametinib was not refrigerated for four hours

Trametinib tablets will be stored refrigerated at 2°C to 8°C (36°F to 46°F) from the original bottles. The patient should not remove the desiccant (the small package contained in the medicine to absorb moisture), protect it from moisture and light, and do not put the medicine in the medicine box. Trametinib oral solution will be stored refrigerated in the original carton at 2°C to 8°C (36°F to 46°F), away from light and moisture. After reconstitution, store in the original bottle below 25°C (77°F). Do not freeze. After 35 days of reconstitution, discard any unused solution.

The mean absolute bioavailability of tramatinib was 72% for oral tablets and 81% for oral solution. Tmax is 1.5 hours. Compared with fasting conditions, a high-fat, high-calorie meal (approximately 1,000 calories) reduced trametinib AUC by 24%, Cmax by 70%, and Tmax by approximately 4 hours. Trametinib’s refrigeration conditions ensure its quality and stability. If trametinib is not refrigerated within four hours, its effectiveness may be affected. It is recommended that trametinib be stored to the appropriate temperature as soon as possible to ensure the quality and effectiveness of the drug.

The original drug of Trametinib has been launched in China and is included in the scope of medical insurance, but it may only be available to patients who meet the indications. The price of 2 mg*30 tablets is more than RMB 10,000. The original drug of Trametinib sold overseas, with the price of 2 mg*30 tablets, is more than RMB 7,000 (the price may fluctuate due to exchange rates). There are also generic trametinib drugs produced in other countries overseas, and their drug ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of a 2mg*30 tablet of a generic drug produced by a Laos pharmaceutical factory is more than 2,000 yuan (the price may fluctuate due to the exchange rate).