What are the precautions for taking Imatinib?

Imatinibis suitable for the treatment of chronic myelogenous leukemia (CML) in adults and children with Philadelphia chromosome mutation(Ph+) after failure of IFN-α blast crisis, accelerated phase or chronic phase. In addition, imatinib is also used to treat adults and childrenPh+acute lymphoblastic leukemia, adult myelodysplasia/myeloproliferative disorders, adult invasive systemic mastocytosis, and adult eosinophilia syndrome. Syndrome and/or chronic eosinophilic leukemia(CEL), adult dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumor(GIST). Imatinib(Imatinib)What are the precautions?

1.Edema and severe fluid retention may occur. Weigh patients regularly and manage unexpected rapid weight gain by interrupting medications and diuretics.

2.Cytopenia, especially anemia, neutropenia and thrombocytopenia may occur. Reduce or interrupt dose, or discontinue treatment. Complete blood counts were performed weekly for the first month, every two weeks for the second month, and periodically thereafter.

3.Severe congestive heart failure and left ventricular dysfunction have been reported, particularly in patients with comorbidities and risk factors. Monitor and treat patients with heart disease or risk factors for heart failure.

4.Severe liver toxicity, including death, may occur. Assess liver function before initiating treatment and monthly thereafter or as clinically indicated. Monitor liver function when used concomitantly with chemotherapy known to be associated with hepatic dysfunction.

5.Grade 3/4 hemorrhage has been reported in clinical studies in newly diagnosed CML patients.

6.Cardiogenic shock/Left ventricular dysfunction is associated with high eosinophil levels(such asHES, MDS/MPD and ASM) are associated with initiation of imatinib mesylate.

7.Hypothyroidism has been reported in thyroidectomy patients receiving levothyroxine replacement therapy, monitor TSH levels closely in such patients.

8.Pregnant women taking this product may cause harm to the fetus. Inform women of the potential harm to the fetus and avoid pregnancy when taking imatinib mesylate tablets.

9.Growth retardation occurs in children and prepubertal children receiving imatinib mesylate. Close monitoring of growth in children receiving imatinib mesylate is recommended.

10.Tumor lysis syndrome. Close monitoring is recommended.

11.Motor vehicle accidents have been reported in patients receiving imatinib mesylate. Remind the patient to drive or operate machinery.

12.Nephrotoxicity. Patients receiving imatinib mesylate may experience a decrease in renal function. Assess renal function at baseline and during treatment and note risk factors for renal dysfunction.

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