How much can you buy bedaquiline in China? Latest reports in 2024

The U.S. Food and Drug Administration (FDA)accelerated approval of Johnson & Johnson's drug bedaquiline (Bedaquiline) for the treatment of drug-resistant tuberculosis (TB) in December 2012. The drug is more popular in India, China and Eastern Europe. Tuberculosis remains a global epidemic.

The unique and specific antimycobacterial activity of bedaquiline originates from the inhibition of the proton pump of mycobacterialATP synthase. ATP synthase is the key enzyme in ATP synthesis in Mycobacterium tuberculosis. Binding of bedaquiline to the oligomeric and proteolipid subunit-c of mycobacterial ATP synthase results in inhibition of ATP synthesis and subsequent bacterial death. The gene encoding the c subunit of ATP synthase is called atpE, and its amino acid sequence is highly conserved among unrelated Mycobacterium tuberculosis isolates. Bedaquiline is a new drug with a new mechanism of action that will not only shorten the treatment time for drug-sensitive tuberculosis, but also treat multi-drug-resistant tuberculosis.

This drug is marketed and sold in China as bedaquiline fumarate tablets, and has been included in the scope of medical insurance. Common specificationsThe price of 100mg*24 tablets per box may be around 10,000 yuan, which is relatively expensive. This drug may be sold in domestic hospitals and other places, but patients must purchase it with a doctor's prescription. The Russian version of bedaquiline sold overseas, Specification100mg*188 tablets per box, may cost around RMB 15,000 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of bedaquiline sold domestically and abroad are basically the same, and there are currently no generic bedaquiline drugs on the market. For specific prices and drug information of overseas drugs, please consult Yaode Medical Consultant.