What are the precautions for taking Ibrutinib?

Ibrutinib is a small molecule drug that inhibits B cell proliferation and survival by irreversibly binding to the protein Bruton's tyrosine kinase (BTK) . Blocking BTKinhibits the B cell receptor pathway, which is often hyperactive in B cell carcinomas. Therefore, ibrutinib is used to treat this type of cancer, including mantle cell lymphoma, chronic lymphocytic leukemia (CLL), andWaldenströ's macroglobulinemia.

Ibrutinib(Ibrutinib)What are the precautions?

1.Ibrutinibmay cause bleeding problems and may lead to death. The risk of bleeding may be increased if you are also taking blood thinners. Tellyour doctor if you have any signs of bleeding, including if there is blood or black stool, pink or brown urine, bleeding pan>, vomiting blood or vomit, coughing up blood, bruising, dizziness, headache or severe headache

2.Infection may occur during ibrutinibtreatment. These infections can be serious and can lead to death. If you develop fever, chills, weakness, confusion, or other symptoms of infection duringibrutinibtreatment, tell yourdoctor immediately.

3.Heart problems. Serious heart rhythm problems, heart failure, and death have occurred in patients treated with ibrutinib, especially in patients who are at increased risk for heart disease, have infections, or have had heart rhythm problems in the past. Tellthe doctor if the patientexperiences any symptoms of a heart problem, such as feeling like a fast and irregular heartbeat, dizziness, lightheadedness, shortness of breath, swelling of the feet, ankles, or legs, chest discomfort, or fainting. If any of the above symptoms occur, your doctor may order a heart test (ECG) and may change your ibrutinib dose.

4.High blood pressure. AcceptibrutinibNew or worsening hypertension in treated patients. The doctor may recommend that the patient start taking antihypertensive medications or change existing medications to treat blood pressure.

5.The number of blood cells decreases. Reductions in blood cell counts (white blood cells, platelets, and red blood cells)are common in patients with ibrutinib but can also be serious. Doctorsshould perform monthly blood tests to check blood cell counts.

6.Second primary cancer. New cancers, including cancers of the skin or other organs, develop during treatment with ibrutinib.

Tumor lysis syndrome. TLSis caused by the rapid breakdown of cancer cells. TLScan cause kidney failure requiring dialysis, abnormal heart rhythms, seizures, and sometimes death. The doctor may give the patient a blood test to check for TLS.

7.Embryo-Fetal Toxicity. According to the results of animal experiments, taking ibrutinib by pregnant women can cause harm to the fetus. Administration of ibrutinib in pregnant rats and rabbits during organogenesis resulted in embryo-fetal toxicity, including malformations, at exposures 3-20 times higher than those reported in patients with hematological malignancies. Inform pregnant women of potential risks to the fetus. Advise females of reproductive potential to use effective contraception during treatment with ibrutinib and for 1 month after the last dose.

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