Is it safe to stop taking ibrutinib?

Ibrutinib is a targeted drug that inhibits Bruton tyrosine kinase (BTK)To function, the enzyme is part of a key signaling pathway in certain cancers, especially B cell leukemias and lymphomas. By blocking this pathway, ibrutinib triggers the death of cancer cells. Ibrutinib can be used to treat mantle cell lymphoma, marginal zone lymphoma, Waldenstrom's macroglobulinemia, chronic lymphocytic leukemia (CLL), and small lymphocytic lymphoma. Ibrutinib is also used to treat chronic graft-versus-host disease.

A study in "Hematology Oncology" in 2017 pointed out::The median overall survival rate of patients who completely discontinued ibrutinib due to non-infectious adverse events245days(approximately8months). After complete discontinuation of ibrutinib, the median survival rate for patients with progressive CLL decreased to 33 days.

A 2020 study in The Oncologist found that about 25% of ibrutinib patients experienced sudden or rapid CLL progression with a median interruption period of 8 days. Patients taking ibrutinib for 24 months or longer were more likely to experience flare-ups.

Patients with progressive disease are more likely to experience flares. Symptoms of an outbreak may include body aches, sore lymph nodes, fatigue, fever, night sweats and abdominal pain. This usually resolves once ibrutinib therapy is resumed. However, temporary discontinuation of treatment is common among patients with CLL. According to researchers in the journal Oncologist, at least 40% of patients experience a temporary interruption in treatment. Most commonly, ibrutinib will be discontinued due to side effects or medical procedures. Due to the risk of bleeding, ibrutinib is contraindicated in surgical patients. There are generic drugs in Bangladesh, Laos and India, with different manufacturers, different specifications, and different prices. The price per box is about 1000 to 2000More than 2000, patients can choose the drug version according to their own financial situation. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.