What is the dosage of everolimus?

Everolimusis a prescription drug used to prevent transplant rejection (anti-rejection drugs)kidney transplant or liver transplant. It is used with the other drugs cyclosporine, corticosteroids, and certain other transplant drugs to prevent rejection of the transplanted kidney. It is used with other medicines called tacrolimus and corticosteroids to prevent rejection of the transplanted liver.

For adult kidney transplant patients, the recommended initial dose of everolimus is 0.75 mg taken orally twice daily (daily 1.5 mg) in combination with a reduced dose of cyclosporine as soon as possible after transplantation. Oral prednisone should be started once oral medications are tolerated. The dose of steroids can be further reduced on an individualized basis based on the patient's clinical status and graft function. Everolimus should be started at least 30 days after transplantation. For adult liver transplant patients, the recommended initial dose is 1 mgorally twice daily (2 mg daily) in combination with reduced-dose tacrolimus.

Patients receiving everolimus may require dose adjustments based on achieved everolimus plasma concentrations, tolerability, individual response, changes in concomitant medications, and clinical circumstances. Optimally, dose adjustments of everolimus should be based on trough concentrations obtained 4 or 5 days after the previous dose change. If trough concentrations are less than3 ng/mL, dose adjustment is required. The total daily dose of everolimus should be doubled using the available tablet strengths (0.25 mg, 0.5 mg, or 0.75 mg). If the trough concentration measured on two consecutive occasions is greater than 8 ng/mL, a dose adjustment is also required; the dose of everolimus should be reduced by 0.25 mg twice daily. There are regular generic drugs on the market in India, IndiaGlenmarkPharmaceutical retail price5mg10tablets900yuan, 10mg10 tablets1500yuan. IndiaciplaPharmaceutical retail price5mg10tablets860yuan, 10mg10tablets1300yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.