How does everolimus work? What is the mechanism of action?

Everolimusis aselective immunosuppressant for the treatment of postmenopausal women with advanced hormone receptor-positive, HER2negative breast cancer in combination with exemestane after failure of letrozole or anastrozole. Everolimus for the treatment of adults with progressive, well-differentiated, non-functional gastrointestinal (GI) or pulmonary neuroendocrine tumors (NET) that are unresectable, locally advanced or metastatic. EverolimusAdults with renal angiomyolipoma and tuberous sclerosis complex(TSC) do not require immediate surgery. Everolimus is used to prevent rejection of kidney and liver transplants.

Everolimus inhibits the activation and proliferation of T and B lymphocytes stimulated by antigens and interleukins (IL-2 and IL-15). In cells, everolimus binds to the cytoplasmic protein FK506binding protein-12 (FKBP-12)binds to form an immunosuppressive complex(everolimus:FKBP-12) that binds to and inhibits the mammalian target of rapamycin(mTOR), a key regulatory kinase. Phosphorylation of mTOR's substrate p70 S6 ribosomal protein kinase (p70S6K) is inhibited in the presence of everolimus. As a result, phosphorylation of ribosomal S6 protein and subsequent protein synthesis and cell proliferation are inhibited. Everolimus:FKBP-12 complex has no effect on calcineurin activity. In rats and nonhuman primate models, everolimus effectively reduces renal transplant rejection and thereby prolongs graft survival. There are generic drugs in India, and each box costs about 1,000 yuan. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.