How long does it take for Ustekinumab injections to be effective?

The dose and frequency of administration of Ustekinumab (Ustekinumab) depend on the disease being treated, and the time to onset of effects depends on the disease being treated. Depending on the condition being treated, improvement usually occurs within 3 weeks with ustekinumab , but it may take up to 8 weeks for some people to see a response.

For Crohn's disease,41% to 51% of adults experienced CDAI 70 at week 3. After 44 weeks, 47% of patients were in clinical remission and were off corticosteroids. For ulcerative colitis, 19% of adults treated with ustekinumab achieved clinical remission at week 8. By week 44, 45% of patients achieved clinical remission and 74% experienced a clinical response. For psoriasis, 66-76% of adults reach PASI 75 after 12 weeks. For psoriatic arthritis, 44%-50% of adults achieve ACR20 and 9%-14% achieve ACR70 after 24 weeks of treatment. Ustekinumab reduces disease activity in most people; however, few achieve remission.

The generic drug Ustekinumab has been launched in China and is included in the medical insurance, and is only reimbursed for patients who meet the indications. The price of the 130mg/26ml intravenous injection preparation may be more than 5,000 yuan per box, and the price of the 90mg: 1.0ml*1 subcutaneous injection preparation may be more than 8,000 yuan per box. The price of the 130mg/26ml intravenous injection preparation of Ustekinumab sold overseas may be more than 2,000 US dollars per box, and the price of 45mg: 0.5ml*1 subcutaneous injection preparation per box may be more than 10,000 US dollars. There are currently no generic versions of ustekinumab produced in other overseas countries.