Are Onvili and Moboxetinib the same drug?

Mobocertinib/Mobocertinib (Mobocertinib) is the same drug as Anvili. It is a trade name used in domestic marketing. The common name is mobocertinib succinate capsules. The common specifications are40mg, it belongs to the third generation of EGFR inhibitors and represents an important progress in the treatment of EGFR mutation-positive non-small cell lung cancer (NSCLC). It aims to provide more effective treatment options and help improve patients' survival and quality of life.

Mobosetinib is an EGFR inhibitor that preferentially targets exon 20 insertion mutation variants. 7 It is available as an oral capsule once daily, with or without food. Mobosetinib can cause a concentration-dependent increase in the QTc interval, which may lead to life-threatening complications such as torsades de pointes. Patients with baseline risk factors for QTc prolongation should have alternative agents considered or carefully monitored throughout treatment. Concomitant use of drugs that prolong QTc should be avoided, as should combined inhibitors of CYP3A, as these drugs may increase its concentration and thereby increase the risk of QTc prolongation.

The domestically marketed Mobosetiniboriginal drug has not yet been included in the medical insurance. The price of the specification40mg*112 pills per box is around 40,000 yuan, which is very expensive.The Hong Kong version of the original drug specification40mg*30 pills per box is priced at more than 7,000 yuan (the price may fluctuate due to the exchange rate). Generic drugs of Mobotinib have also been put on the market for sale overseas. The drug ingredients are basically the same as those of the original drugs at home and abroad. For example, the production specifications of Laos Pharmaceutical Factory40mg*120 pills per boxThe pricemay be more than 4,000 yuan (the price may fluctuate due to the exchange rate), and the price is relatively cheap.