Is there a big difference between moboxetinib and osimertinib?

Mobocertinib and Osimertinib are two drugs used to treat non-small cell lung cancer (NSCLC). They are drugs targeting different types of EGFR mutations and have different targeting mechanisms and clinical application scopes. There are some differences in their mechanisms of action, indications and clinical data. When choosing a treatment option, doctors consider a patient's specific condition and type of mutation to determine the most appropriate drug.

1. Mechanism of action: Mobosetinib and osimertinib are both tyrosine kinase inhibitors (TKIs), but they act on different targets. Mobosetinib mainly inhibits the EGFR exon 20 mutation (Exon 20 insertion mutation), while osimertinib mainly inhibits the EGFR exon 21 point mutation (Exon 21 point mutation), that is, L858R and exon 19 deletion. The difference between the two is only the presence of an additional C5-carboxylic acid isopropyl ester group on the middle pyrimidine core.

2. Indications: Mobosetinib is currently approved for the treatment of non-small cell lung cancer patients who have received other EGFR-TKI treatments and have EGFR exon 20 mutations. Osimertinib is approved for the treatment of patients with EGFR exon 21 point mutations who have received other EGFR-TKI treatments. It is also suitable for patients with metastatic non-small cell lung cancer with EGFR T790M mutations.

3. Drug resistance: Osimertinib is a third-generation EGFR inhibitor that is currently widely used. It is mainly used to treat drug resistance caused by multiple mutations. Mobosetinib is a new type of EGFR inhibitor that is highly sensitive to Exon 20 mutations.

4. Side effects: Although both drugs can cause some common side effects, such as nausea, vomiting, rash, etc., moboxetinib may cause more serious side effects, such as interstitial lung disease, pulmonary fibrosis, etc. In contrast, osimertinib's side effects are mild.

MobosetinibThe original drug is currently on the market in China and has not been included in medical insurance. SpecificationsThe price of 40 mg*112 pills per box is about 40,000 yuan, which is very expensive.The Hong Kong version of the original drug Specifications40 mg*30 pills per boxThe price is more than RMB 7,000 (the price may fluctuate due to exchange rates). Generic drugs of Mobotinib have also been put on the market for sale overseas. Its pharmaceutical ingredients are basically the same as those of the original drugs at home and abroad. For example, the production specifications of Laos Pharmaceutical Factory 40mg*120 pills per box may be more than 4,000 yuan (the price may fluctuate due to the exchange rate), and the price is relatively cheap.