What is the longest resistance time to mobosetinib?

Mobocertinib is a targeted lung cancer drug used to treat non-small cell lung cancer with EGFR (epidermal growth factor receptor) gene mutations. The duration of resistance can vary depending on individual differences, disease characteristics, and treatment regimens.

According to clinical trial data, mobosetinib has shown a good effect in prolonging the resistance time in patients with treatment resistanceEGFR mutations. The mean absolute bioavailability of moboxetinib is 37%, with a median Tmax of approximately 4 hours. After a single oral dose of 160 mg of mobosertinib in fasting patients, the mean Cmax and AUC0-inf were 45.8 ng/mL and 862 ng/mL, respectively. However, since mobosetinib is in a relatively new clinical trial phase, there is no large-scale long-term resistance data available for reference. The time of drug resistance is a complex issue and is affected by many factors, such as tumor characteristics, gene mutations, treatment options and individual patient differences. The duration of resistance may vary in each patient.

Mobosetinib The original drug is currently on the market in China and has not yet been included in the medical insurance. SpecificationThe price of 40mg*112 pills per box is about 40,000 yuan, which is very expensive.The Hong Kong version of the original drug Specifications40mg*30 pills per box is priced at more than 7,000 yuan (the price may fluctuate due to exchange rates). Generic drugs of Mobotinib have also been put on the market for sale overseas. Its pharmaceutical ingredients are basically the same as those of the original drugs at home and abroad. For example, the production specifications of Laos Pharmaceutical Factory 40mg*120 pills per box may be more than 4,000 yuan (the price may fluctuate due to the exchange rate), and the price is relatively cheap.