Must understand! What is the dosage of bedaquiline?

Bedaquiline (Bedaquiline) is a diarylquinoline antimycobacterial drug indicated for the combination treatment of adult and pediatric patients (5 years and older and weighing at least 15kg) with multidrug-resistant tuberculosis (MDR-TB). Reserve bedaquiline for use when effective treatment options are unavailable. Before treatment with bedaquiline, if possible, background protocol information on susceptibility to Mycobacterium tuberculosis, electrocardiogram, serum potassium, calcium and magnesium concentrations, liver enzymes, etc. Bedaquiline is administered via directly observed therapy (DOT).

The recommended dose of bedaquiline for adults is 400 mg (4 of 100 mg tablets or 20 of 20 mg tablets) taken orally once daily for weeks 1 and 2, followed by From 3 weeks to 24 weeks, the recommended dose is 200 mg (2 of 100 mg tablets or 10 of 20 mg tablets) taken orally three times per week, with at least 48 hours between doses and must be taken with food.

The recommended dose of bedaquiline in children is based on body weight.For patients under 15kg-30kg, the recommended dose is 200mg (2 of 100mg tablets or 10 of 20mg tablets) orally once daily in weeks 1 and 2, followed by weeks 3 The recommended dose is 100 mg (1 of 100 mg tablets or 5 of 20 mg tablets) orally three times weekly; for patients over 30 kg, the recommended dose is the same as for adults. The total duration of bedaquiline treatment in pediatric patients is 24 weeks.

Bedaquiline20mg is a functional scored tablet that can be divided into two equal portions of 10mg each at the score line to provide a dose of less than 20mg. Take the entire tablet with water. As an alternative method of administration, bedaquiline 20 mg tablets may be administered dispersed in water, or dispersed in water and further mixed with a beverage or soft drink, or crushed and mixed with a soft drink, or administered through a feeding tube.

The drug is sold in China under the name of daquiline fumarate tablets and has been included in the scope of medical insurance. The price of a common specification of 100mg*24 tablets per box may be around 10,000 yuan, which is relatively expensive. The price of the Russian version of Bedaquiline sold overseas, Specifications100mg*188 tablets per box, may be around RMB 15,000 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of Bedaquiline sold domestically and abroad are basically the same. Currently, there are no generic bedaquiline drugs produced and marketed overseas. For specific prices and drug information of overseas drugs, please consult Yaode Medical Consultant.