The best combination of bedaquiline has been clarified!

Bedaquiline (Bedaquiline) can be used in combination with a variety of anti-tuberculosis drugs to form different treatment options. Different treatment options are suitable for different patients, and the appropriate option should be selected according to the patient's specific conditions to ensure safety and effectiveness. Some common combinations include:

1. Bedaquiline and rifampicin: Rifampicin is a broad-spectrum antibiotic commonly used to treat tuberculosis. The combination of bedaquiline and rifampicin enhances the inhibitory effect against Mycobacterium tuberculosis.

2. Bedaquiline and isoniazid: Isoniazid is a single bactericide that can destroy the cell wall of Mycobacterium tuberculosis. The combination of bedaquiline and isoniazid may enhance the effectiveness of tuberculosis treatment.

3. Bedaquiline, rifampicin and ethambutol: Ethambutol is also an anti-tuberculosis drug that can inhibit the growth of Mycobacterium tuberculosis. A combination of bedaquiline, rifampicin, and ethambutol can be used to treat TB patients who are resistant to other drugs.

Although bedaquiline is generally safe, the results of its phase II clinical trial showed excess mortality and QT interval prolongationThe US Food and Drug Administration (FDA) also issued a "black box" warning.

The drug is sold in China under the name of daquiline fumarate tablets and has been included in the scope of medical insurance. The price of a common specification of 100mg*24 tablets per box may be around 10,000 yuan, which is relatively expensive. The price of the Russian version of Bedaquiline sold overseas, Specifications100mg*188 tablets per box, may be around RMB 15,000 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of Bedaquiline sold domestically and abroad are basically the same. Currently, there are no generic bedaquiline drugs produced and marketed overseas. For specific prices and drug information of overseas drugs, please consult Yaode Medical Consultant.