Is bedaquiline effective? How long can one box last?

Bedaquiline (Bedaquiline) is a dihydrofolate reductase inhibitor that treats tuberculosis by preventing the growth of Mycobacterium tuberculosis in the human body. Due to its unique antibacterial mechanism of action and effectiveness against multiple drug-resistant strains, bedaquiline is widely considered to be one of the important weapons in the treatment of multidrug-resistant tuberculosis. But it doesn’t work for all TB patients. Due to its strong bactericidal effect, it may lead to a further increase in drug resistance of Mycobacterium tuberculosis. Therefore, it is necessary to strictly abide by the doctor's instructions when using bedaquiline and closely monitor the patient's condition and drug resistance. The safety profile of bedaquiline varies among different populations, and caution should still be used when using it. Bedaquiline may cause some adverse reactions and side effects, including nausea, vomiting, headache, joint pain, rash, dizziness, elevated transaminases, elevated blood amylase, diarrhea and QT interval prolongation.

The drug is marketed in China under the name of daquiline fumarate tablets and has been included in the scope of medical insurance. The price of a common specification of 100mg*24 tablets may be around 10,000 yuan per box, which is relatively expensive. Patients can take one box of this specification for about a week. The Russian version of bedaquiline sold overseas, Specifications100mg*188 tablets, may cost around 15,000 yuan per box (the price may fluctuate due to exchange rates). Patients with this specification can take one box for about 6 months (one course of treatment). The pharmaceutical ingredients of bedaquiline sold domestically and abroad are basically the same. Currently, there are no generic bedaquiline drugs produced and marketed overseas. For specific prices and drug information of overseas drugs, please consult Yaode Medical Consultant.