Bedaquiline’s cure rate for tuberculosis is beyond imagination

Bedaquiline (Bedaquiline) has a significant effect in the treatment of multidrug-resistant tuberculosis, with a cure rate of over 90%. Bedaquiline is a new anti-tuberculosis drug with a different mechanism of action from other anti-tuberculosis drugs. It inhibits ATP synthase during the cell wall synthesis of Mycobacterium tuberculosis, thereby interfering with the energy metabolism of bacteria and inhibiting their growth and reproduction.

The main advantage of bedaquiline is that it also has good antibacterial activity against Mycobacterium tuberculosis that is resistant to other anti-tuberculosis drugs. This means that bedaquiline remains an important treatment option for patients who have developed resistance to traditional anti-tuberculosis drugs. In clinical trials, bedaquiline has been proven to be used in combination with other anti-tuberculosis drugs to significantly shorten the treatment time of patients, increase the rate of sputum negative conversion, and reduce the incidence of drug-resistant cases. Compared with conventional treatment, patients who used bedaquiline combined with conventional treatment had significantly higher sputum negative conversion rates after 8 and 24 weeks of treatment.

In addition, bedaquiline demonstrated good safety and tolerability. Although some adverse effects and side effects have been reported, most are mild to moderate and can be controlled and managed. Cardiotoxic effects are the biggest safety concern for bedaquiline, but study results show that its cardiac safety profile is similar to that of placebo at conventional therapeutic doses.

The drug is sold in China under the name of daquiline fumarate tablets and has been included in the scope of medical insurance. The price of a common specification of 100mg*24 tablets per box may be around 10,000 yuan, which is relatively expensive. The price of the Russian version of Bedaquiline sold overseas, Specifications100mg*188 tablets per box, may be around RMB 15,000 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of Bedaquiline sold domestically and abroad are basically the same. Currently, there are no generic bedaquiline drugs produced and marketed overseas. For specific prices and drug information of overseas drugs, please consult Yaode Medical Consultant.