Difference Between Valganciclovir and Ganciclovir

Valcyte is a prodrug of ganciclovir, valganciclovir’s Cmax and The AUCis approximately 1% and 3% of ganciclovir, respectively. VALCYTEContains valganciclovir hydrochloride (valganciclovir hydrochloride), a form of valganciclovir hydrochloride, which exists as a mixture of two diastereoisomers. Ganciclovir is a synthetic guanine derivative with activity against cytomegalovirus.

After oral administration, valganciclovir is converted to ganciclovir (the active drug) and, therefore,valganciclovir is expected to have reproductive toxic effects similar to those of ganciclovir. In animal studies, ganciclovir caused maternal and fetal toxicity and embryo-fetal mortality in pregnant mice and rabbits, and teratogenicity in rabbits exposed to twice the human exposure. There are no available human data on the use of valganciclovir or ciclovir in pregnant women to determine whether there is a drug-related risk. The background risk of major birth defects and miscarriage in these populations is unknown. However, in the general U.S. population, the background risk of major birth defects is 2-4% and the risk of miscarriage is 15-20% of clinically recognized pregnancies. Inform pregnant women of potential risks to the fetus.

Animal data indicate that ganciclovir is secreted in the milk of lactating rats. The Centers for Disease Control and Prevention recommends that HIV-infected mothers not breastfeed their infants to avoid the risk of transmitting HIV after birth. Nursing mothers are advised not to breastfeed during treatment with valganciclovir due to the potential for serious adverse events and possible transmission of HIV to the nursing infant. The retail price of the Turkish version of the original drug in pharmacies0.45g*60tablets2 is more than a thousand. The retail price of original medicine in India is about 0.45g*60 tablets4 around one thousand. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.