What kind of medicine is Sotolaxib (AMG510)? What is the effect?

Sotoracib (AMG510) is a drug called a KRAS inhibitor. It works by blocking the activity of abnormal proteins that signal cancer cells to multiply. This helps prevent or slow the spread of cancer cells. Sotoracib is used to treat certain types of lung cancer (non-small cell lung cancer; non-small cell lung cancer) that have spread to other parts of the body or in adults who have received at least one other treatment that cannot be removed with surgery.

Sotorasiib is the world's first targeted drug for KRAS G12C mutation, and has a remarkable effect in treating cancer. Sotoracib ( is a small molecule that selectively and irreversibly targets KRASG12C.KRAS G12C mutations occur in 13% of non-small cell lung cancers (NSCLCs) and /span>1-3%of colorectal and other cancers were studied in patients with advanced solid tumors. an> phase trial, a total of 129patients(59patientsNSCLC Patients, 42 colorectal cancer patients, 28 patients with other tumors )Patients were included in the dose escalation and expansion cohorts who had received a median of 3 (range 0-11)< No dose-limiting toxicities or treatment-related deaths were observed in 73 patients(56.6). %)Treatment-related adverse events occurred;15patients(11.6%)occurred< /span>Grade 3 or Grade Grade 4 events in the NSCLC subgroup.32.2% (19patients)had definite objective response (complete or partial response), 88. 1% (52 patients pan>(ranges from 0.0+ to 14.9[where + indicates that the value includes patient data censored at the time of data cutoff]). In the subgroup with colorectal cancer, 7.1% (3patients) had a confirmed response and 73.8% (31patients)had disease control; median progression-free survival was 4.0 months< /span>(The range is 0.0+ to 11.1+). Responses were also observed in patients with pancreatic cancer, endometrial cancer, appendiceal cancer, and melanoma. Sotoracib(Shows promising anti-cancer activity in patients with heavily pretreated advanced solid tumors harboring KRAS p.G12C mutations.If you want to get more high-quality information, you can contact YaDE, YaDE will do its best to learn more about high-quality overseas drugs for you.

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