Pazopanib/Pazopanib (Pazopanib) mechanism of action

Pazopanib is a prescription medicine indicated for the treatment of advanced renal cell carcinoma (RCC) in adults. Pazopanib is also indicated for the treatment of adult patients with advanced soft tissue sarcoma (STS) who have previously received chemotherapy. Pazopanib/Pazopanib is a potent and selective multi-target receptor tyrosine kinase inhibitor that can block tumor growth and inhibit angiogenesis.

Pazopanib is a vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, VEGFR-3, platelet-derived growth factor receptor (PDGFR)-ɑ and -β, fibroblast growth factor receptor (FGFR) -1 and -3, cytokine receptor (Kit), interleukin -2 receptor InducibleTcellular kinase (Itk), lymphocyte-specific protein tyrosine kinase (Lek) and transmembrane glycoprotein receptor tyrosine kinase (c Fms) polytyrosine In vitro, pazopanib inhibits ligand-induced autophosphorylation of VEGFR-2, Kit, and PDGFR-β receptors in vitro. In vivo, pazopanib inhibits VEGF-induced phosphorylation of VEGFR-2 in mouse lungs, angiogenesis in mouse models, and the growth of certain human tumor xenografts in mice.

The binding rate of pazopanib to human plasma proteins in vivo is 99%, with no concentration dependence in the range of 10 to 100 mcg/mL. In vitro studies show that pazopanib isSubstrate of P-gp and BCRP. The mean half-life of pazopanib is 31 hours after administration at the recommended dose of 800 mg. In vitro studies have shown that pazopanib is metabolized by CYP3A4, with minor involvement of CYP1A2 and CYP2C8. Pazopanibis mainly excreted through feces, and renal excretion accounts for 4% of the administered dose. There are generic drugs in Bangladesh, and the retail price of Bangladesh Yaopin International Pharmaceuticals is about 200mg 30 tablets 600 yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.