How long does Pazopanib stay in the body?

Pazopanib is an oral once-daily tablet indicated for the treatment of soft tissue sarcoma in adults who have received prior chemotherapy or advanced renal cell carcinoma (RCC). Pazopanib can stay in the body for about 5 to 6.5 days. Based on the half-life of pazopanib is about 31 hours, experts believe that a drug without active metabolites requires 5 half-lives to be completely eliminated from the body. The half-life of a drug is the time it takes for 50% of the drug to be eliminated from the body. This means that it takes 124to155 hours for pazopanib to leave the body.

The recommended dose of pazopanib tablets is800 mg (four tablets200 mgtablets), once daily without food (at least 1 hours before meals or 2 hours after meals) until disease progression or unacceptable toxicity occurs. For patients with hepatic impairment and those taking certain concomitant medications, the dose should be adjusted. Avoid consuming grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase pazopanib serum concentrations. Avoid use of St. John's wort, which induces CYP3A4 metabolism, which may decrease pazopanib serum concentrations. Separate pazopanib from meals at least1hour before or after meals because food increases the bioavailability of pazopanib. Separate administration with antacids by several hours between the administration of pazopanib and antacids. There are generic drugs in Bangladesh, and the retail price of Bangladesh Yaopin International Pharmaceuticals is about 200mg 30 tablets600 yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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