Can tumors shrink while taking pazopanib?

Pazopanibcan shrink or slow the growth of kidney cancer in some people, and the effect is more pronounced in patients who have not been previously treated. Pazopanibmay improve progression-free survival in a trial involving 435 patients with locally advanced or metastatic kidney cancer. The average progression-free survival was 9.2 months for patients taking zopanib, compared with 4.2 months for those taking placebo (the inactive treatment).

Pazopanib is a targeted cancer drug that is a tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins that act as chemical messengers (enzymes) in cells. There are many different tyrosine kinases that stimulate the growth of cancer cells. Pazopanib blocks many of these proteins and is called a polytyrosine kinase inhibitor (polyTKI). It prevents cancer cells from forming the blood vessels they need to grow. This is called an anti-angiogenic treatment.

The most common side effects of pazopanib are nausea, vomiting, diarrhea (occurring in about half of patients), hair color changes, hypertension, loss of appetite, and hyperglycemia, Hypoglycemia and electrolyte abnormalities (including hypocalcemia, Hypomagnesemia, Hypophosphatemia), laboratory abnormalities, edema, hair loss or discoloration, taste changes, abdominal pain, rash, fatigue and bone marrow suppression(Including leukopenia, neutropenia, Thrombocytopenia and lymphopenia). There are generic drugs in Bangladesh. The retail price of Bangladesh Yaopin International Pharmaceuticals200mg30 tablets is about 600 yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.