What versions of cabozantinib are available and how should patients choose?

Cabozantinib (Cabozantinib) was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the United States under the trade name Cometriq for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved to treat advanced renal cell carcinoma. In 2019, the agent received additional approval in the United States and Canada for the treatment of hepatocellular carcinoma in previously treated patients.

Cabozantinib blocks tyrosine kinase activity. These enzymes can be found in certain receptors on cancer cells, and they are involved in activating processes such as cell division and the growth of new blood vessels to supply the cancer. By blocking the activity of these enzymes in cancer cells, this drug can reduce the growth and spread of cancer.

The original drug Cabozantinib is not marketed in the country and therefore cannot be included in medical insurance. There are Japanese, Turkish and European versions of the original cabozantinib drug marketed overseas. The price of the Japanese version and Turkish version of the tablet may be more than more than 30,000 yuan, and the price of the European version of the capsule preparation may be more than 40,000 yuan (the price may fluctuate due to the exchange rate). Currently, only these versions of the original drug of cabozantinib are known.

There are also generic drugs produced in other countries overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs. Common pharmaceutical factories include Laos No. 2 Factory, Bangladesh Yaopin International, etc. For example, the price of the Bangladesh pharmaceutical factory may be more than more than 2,000 yuan, and the price of the Laos pharmaceutical factory may be more than 1,000 yuan (the price may fluctuate due to the exchange rate). The price is relatively cheap, and the difference lies in specifications, manufacturers, etc. For specific prices and drug details, please consult Yaode Medical Consultant.