Can cabozantinib treat bone metastases caused by lung cancer?

Cabozantinib (Cabozantinib) is not a special drug only for lung cancer bone metastasis, but an oral anti-cancer drug widely used to treat malignant tumors such as kidney cancer, liver cancer, and thyroid cancer. It mainly blocks tumor growth, angiogenesis and metastasis by inhibiting active tyrosine kinases in multiple key signaling pathways, thereby slowing or stopping tumor progression.

Cabotinib is a small molecule methionine/HGF inhibitor that is thought to have a greater effect on bone metastasis because it targets the VEGF receptor that is upregulated in renal cell carcinoma and methionine, an important signaling pathway in osteoblasts and osteoclasts. However, according to the prescription guidelines, cabozantinib cannot yet be used to treat lung cancer, and it is not effective for all patients with bone metastases from lung cancer. The specific effect needs to be determined based on the patient's specific situation and individual differences. For patients with lung cancer bone metastasis, certain drugs can inhibit multiple signaling pathways in the bone resorption process, reduce bone destruction and bone pain, and improve bone-related symptoms and quality of life related to bone metastasis. In addition, it can also exert an inhibitory effect on the growth, differentiation and proliferation of tumor cells.

The original drug Cabozantinib is not marketed in the country and therefore cannot be included in medical insurance. The original cabozantinib drug marketed overseas includes Japanese, Turkish and European versions. The price of tablets may be more than 30,000 yuan, and the price of capsule preparations may be more than 40,000 yuan (prices may fluctuate due to exchange rates). There are also generic drugs produced in other countries overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs. For example, the price of pharmaceuticals produced by Bangladeshi pharmaceutical factories may be more than 2,000 yuan (the price may fluctuate due to the exchange rate), which is relatively cheap.