The difference between adagrasib and sotoracib (AMG510)

Currently targetingKRAS There are only two drugs targeting G12Cmutations in the worldadagrasib and sotorasibu (AMG510). Sotoraxib is the first KRAS approved after nearly 40 years of research.KRAStargeted drug, which was approved for marketing in20215Menstrual AmericaFDA, and adagrasib is the second KRAS approved for marketing G12Cinhibitors.

The R&D manufacturers of adagratib and sotolatib are different.

Sotorasibu was developed by Japan's Amgen (Amgen), and adagrasibu was developed by Mirati Therapeutics. The launch times are different, sotorasiib will be released in20215Menstrual America FDA has been approved for marketing, and adagrasib has been launched in the United States in December 2022.

There are different dosages of adagrasib and sotorasib

The recommended dose of adagrasiib is 600 mg orally twice daily until disease progression or unacceptable toxicity. The recommended dose of sotoraxib is 960 mg per day, taken orally once a day, until disease progression or unacceptable toxicity occurs.

Clinical data differ between adagrasiib and sotorasiib

Half-life of adagrasib23 hours, disease control rate (DCR)96%, objective response rate (ORR) 45%, duration of response (DOR) 6.5 months, median progression-free survival (mPFS) 11.1 months, median overall survival (mOS< span>)12.6 months, the incidence of adverse reactions is 85%, and the incidence of adverse reactions grade 3 or above is 30%. The half-life of sotoraxib5.5 hours, disease control rate (DCR) 80.6%, objective response rate (ORR)37.1%, duration of response (DOR) 6.8 months, median no Progression survival (mPFS) 13.6 months, median overall survival (mOS) 12.5 months, the incidence rate of adverse reactions69.8%, and the incidence rate of adverse reactions grade 3 or above 19.8%. The above is for reference only. The retail price of Everest Pharmaceuticals in Bangladesh120mg56tablets4more than a thousand, the retail price of Ziska Pharmaceuticals in Bangladesh120mg56tablets3More than a thousand, old The retail price of Laos Element Pharmaceuticals120mg56capsules4 is more than a thousand, and the retail price of Laos Lucius Pharmaceuticals120mg56capsules2000yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.