Cabozantinib mechanism of action

Cabozantinibis amultikinase inhibitor, suitable for the treatment of progressive metastatic medullary thyroid carcinoma(MTC), suitable for combination with nivolumab for the treatment of advanced renal cell carcinoma(RCC) First-line treatment, suitable for hepatocellular carcinoma(HCC) who have previously received sorafenib treatment Patients for adults with locally advanced or metastatic differentiated thyroid cancer that have progressed after prior VEGFR targeted therapy(DTC ),and adults who are refractory or ineligible for radioactive iodine.

Mechanism of action of cabozantinib: In vitro biochemistry and / or cell assays show that cabozantinib inhibits MET and VEGFR-1, -2 and -3, AXL, RET, ROS1, TYRO3, MER, KI Tyrosine kinase activities of T, TRKB, FLT-3, and TIE-2. These receptor tyrosine kinases are involved in normal cellular functions and pathological processes, such as tumorigenesis, metastasis, tumor angiogenesis, drug resistance, and maintenance of the tumor microenvironment.

Cabozantinibis a kinase inhibitorthe (S)-malate salt of Cabozantinib. Cabozantinib (S)-malate is chemically described as N-(4-(6, 7-dimethoxy Quinoline-4-yloxy)phenyl)-N’-(4-fluorophenyl)Cyclopropane-1, 1-dicarboxylamide, (2S)-hydroxysuccinate. The molecular formula is c 28h 24 fn 3 o 5 C4 h6 o 5, and the molecular weight is 635.6Dalton, which is malate. CarboBoTinib(S)-malate is a white to off-white solid that is almost insoluble in aqueous media. Oral cabozantinib tablets are available as film-coated tablets containing 20 mg, 40 mg, or 60 mg cabozantinib, equivalent to 25 mg, 51 mg, respectively. mgor 76mg Caboozantinib (S)-malate. Cabozantinib also contains the following inactive ingredients: Microcrystalline cellulose, lactose anhydrous, hydroxypropyl cellulose, croscarmellose sodium, colloidal silicon dioxide, and magnesium stearate. Lao ASEAN Pharmaceuticals, United Pharmaceuticals, Lucius Pharmaceuticals, Element Pharmaceuticals, etc. are produced, and the cost per box is less than 20mg*90pills1,000 yuan. The retail price of Everest Pharmaceuticals, Yaopin International and Beacon Pharmaceuticals in Bangladesh is around 20mg*90 capsules 2000 per box. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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