Cabozantinib usage and dosage

Cabozantinibis a small molecule drug used to treat patients with advanced renal cell carcinoma (RCC), including with Opdivo (nivolumab) in combination as first-line treatment, and in patients with hepatocellular carcinoma (HCC) who have been previously treated with Nexavar (sorafenib). It is also used to treat differentiated thyroid cancer that has spread and progressed after VEGFR-targeted therapy in patients who can no longer be treated with radioactive iodine or who cannot receive that treatment. Cabotinib is a tyrosine kinase inhibitor that works by helping to stop the uncontrolled growth that cancer cells exhibit. Take once daily.

Cabotinib S-malate It is administered orally in the form of capsules or tablets. CabotinibCapsules:Take orally once daily. Do not take with food; do not eat ≥2 hours before and ≥1 hours after taking cabozantinib capsules. Swallow the entire capsule with a full glass of water without opening or squeezing the capsule. CaboozantinibTablets:Take orally once daily. This drug should not be taken with food, and patients should not eat ≥2 hours before and ≥1 hours after taking cabozantinib. Caboozantinib should be swallowed whole and the tablet should not be crushed. If you miss a dose of cabozantinib, do not take the missed dose within 12 hours of your next dose.

Avoid co-administration with CYP3A4 strong inhibitor drugs. If concomitant use cannot be avoided, reduce the daily dose of cabozantinib(Caboozantinib)Reduce 20 mg (For example, for pediatric patients with BSA <1.2 m, daily 60 mg to 40 mg, or daily 40 mg to 20 mg, or daily 20 mg to every other day 20 mg2).If you discontinue a strong CYP3A4 inhibitor, then discontinue a strong CYP3A4inhibitor After 2-3 days, return the dose of cabozantinib to the dose before starting the strong CYP3A4 inhibitor. Laos ASEAN Pharmaceuticals, United Pharmaceuticals, Lucius Pharmaceuticals, Element Pharmaceuticals, etc. are produced, and the cost per box is less than 20mg*90 capsules1,000 yuan. The retail price of Everest Pharmaceuticals, Yaopin International and Beacon Pharmaceuticals in Bangladesh is around 20mg*90 capsules 2000 per box. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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