What are the targets of cabozantinib?

Cabozantinib is a kinase inhibitor that inhibits MET and VEGFR-1 , -2 and -3, AXL, RET, ROS1, TYRO3, MER, KIT, TRKB, FLT-3, and TIE-2. These receptor tyrosine kinases are involved in normal cellular functions and pathological processes, such as tumorigenesis, metastasis, tumor angiogenesis, drug resistance, and maintenance of the tumor microenvironment.

CabotinibSide effects include (Incidence≥25%):Diarrhea, stomatitis, palms-Plantar dysesthesia syndrome(Hand-foot syndrome), weight loss, decreased appetite, nausea, fatigue, oral pain, hair color change, dysgeusia, hypertension, abdominal pain, constipation, increased AST concentration, increased ALT concentration, lymphopenia, increased alkaline phosphatase concentration, hypocalcemia, neutropenia, thrombocytopenia, hypophosphatemia, hyperbilirubinemia.

CabotinibSide effects include (incidence≥20%):diarrhea, fatigue, palmar-Plantersal dysesthesia syndrome(Hand-foot syndrome), decreased appetite, hypertension, nausea, vomiting, weight loss, and constipation.

Cabozantinib combined withnivolumab Side effects include (incidence≥20%):diarrhea, fatigue, hepatotoxicity, palmar-Plantar red blood cell dysesthesia syndrome(Hand-foot syndrome), stomatitis, rash, hypertension, hypothyroidism, musculoskeletal pain, decreased appetite, nausea, dysgeusia, abdominal pain, cough, upper respiratory tract infection. Lao ASEAN Pharmaceuticals, United Pharmaceuticals, Lucius Pharmaceuticals, Element Pharmaceuticals, etc. are produced, and the cost per box is less than 20mg*90pills1,000 yuan. The retail price of Everest Pharmaceuticals, Yaopin International and Beacon Pharmaceuticals in Bangladesh is around 20mg*90 capsules 2000 per box. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.

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