What does mitotane treat? What kind of medicine is it?

Mitotane (Mitotane) is the only drug approved for the treatment of advanced adrenocortical cancer and is increasingly used as postoperative adjuvant therapy. Mitotane is known to disrupt the adrenal cortex and impair steroidogenesis, although the exact molecular mechanisms remain unclear. However, confounding factors affecting in vitro experiments may reduce the relevance of the study.

The effects of mitotane include dysregulation of cytochromeP450 enzymes, depolarization of mitochondrial membranes and accumulation of free cholesterol, leading to cell death. Although mitotane is known to disrupt the adrenal cortex and impair steroidogenesis, its exact mechanism of action remains unclear. The most commonly used cell models are H295-derived cell lines and SW13 cell lines. The different results obtained in potentially identical cell lines highlight the need for stable in vitro models and/or standard methods to conduct experiments with the H295 strain. When cells are exposed to mitotane, the presence of several mitotane-responsive enzyme targets in mitochondria and mitochondria-associated membranes leads to progressive changes in mitochondrial structure. Confounding cultural factors affecting in vitro experiments may reduce the importance of any molecular mechanism identified in vitro.

The original drug of mitotane has been launched in China, but it has only been on the market for a short time, its purchase is very difficult, and it is not included in medical insurance. Mitotane marketed overseas The original drug has European and Turkish versions, specificationsThe price of 500mg*100 tablets per box may be more than 9,000 yuan (the price may fluctuate due to exchange rates). Mitotan generic drugs are also sold overseas, and their drug ingredients are basically the same as those of the original drug. For example, the specifications produced by Laos pharmaceutical factoriesThe price of 500mg*100 tablets per box may be more than 3,000 yuan (prices may fluctuate due to exchange rates).