What are the contraindications when taking mitotane?

There are some contraindications that need to be noted when taking Mitotane (Mitotane). Here are some things to note:

1. Patients allergic to mitotane or its components: If you have ever been allergic to mitotane or its components, you should avoid using mitotane. Anaphylaxis may manifest as rash, itching, hives, difficulty breathing, and other symptoms.

2. Patients with thyroid dysfunction: Mitotane may affect the synthesis and metabolism of thyroid hormones, therefore** patients with hypothyroidism or hyperthyroidism should use mitotane with caution**. The concomitant presence of thyroid dysfunction may result in severe metabolic disturbances.

3. Patients with adrenal dysfunction: Patients with adrenal insufficiency and hyperadrenaline should use mitotane with caution. Mitotane may further reduce the function of the adrenal cortex, causing patients to experience symptoms such as fatigue and hypotension, and may also aggravate the symptoms of hyperadrenaline.

4. Pregnant and lactating women: Pregnant and lactating women should avoid using mitotane. Mitotane may have teratogenic effects on the fetus and should not be used by women who are about to become pregnant, are pregnant, or are breastfeeding. As long as mitotane plasma levels are detectable, female patients of childbearing potential are advised to use effective contraception during treatment and after discontinuation of treatment.

The original drug of mitotane has been launched in China, but it has only been on the market for a short time, its purchase is very difficult, and it is not included in medical insurance. Mitotane marketed overseas The original drug has European and Turkish versions, specificationsThe price of 500mg*100 tablets per box may be more than 9,000 yuan (the price may fluctuate due to exchange rates). Mitotan generic drugs are also sold overseas, and their drug ingredients are basically the same as those of the original drug. For example, the specifications produced by Laos pharmaceutical factoriesThe price of 500mg*100 tablets per box may be more than 3,000 yuan (prices may fluctuate due to exchange rates).