What is the progression-free survival of capmatinib?

Capmatinib belongs to the kinase inhibitor class of drugs. Capmatinib works by blocking the activity of an abnormal protein that sends a reproduction signal to cancer cells. This helps slow down or prevent the spread of cancer cells. Capmatinibsold under the trade name Tabrecta is an anticancer drug used to treat metastatic non-small cell lung cancer in which tumors have mutations that lead to skipping of exon 14 of the MET gene encoding the membrane receptor HGFR.

One study showed that median progression-free survival was 9.5 months (95%confidence interval 4.7-14.3) compared with 10.6 months (95% ) in first-line patients CI, 5.5–15.7), and 9.1 months (95% CI, 3.1–15.1) in pretreated patients. After a median follow-up of 11.0 months, the median overall survival was 18.2 months (95% CI, 13.2–23.1).

It is estimated that the oral bioavailability of capmatinib is 70%. After oral administration, the maximum plasma concentration (Tmax), administration with a high-fat meal increased the AUC of capmatinib by 46%, whereas C had the greatest no change (compared to fasted conditions), and administration with a low-fat meal had no clinically meaningful effect on exposure. The apparent volume of distribution at steady state is 164 L. The plasma protein binding rate is approximately 96% and has nothing to do with the serum concentration of the drug. CapmatinibMainly passedCYP3A4and aldehyde oxidase for metabolism. The specific biotransformation pathways and metabolites have not yet been elucidated. After oral administration of radiolabeled capmatinib, approximately 78% of the radioactivity is recovered in feces, of which approximately 42% is unchanged parent drug, and 22% is recovered in urine, of which a negligible amount remains unchanged parent drug. The elimination half-life is 6.5 hours. The average apparent clearance of capmatinib at steady state is 24 L/h3. If you want to get more high-quality information, you can contact YaoDe. YaoDe will do its best to learn more about high-quality overseas drugs for you.